Project I. Modulate gut microbiome to protect brain functions
(1) Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome. [Full article]
(2) Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice. [Full article]
(3) Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. [Full article]
The project is funded by NIH/NIA RF1AG062480 and NIH/ODS R01AG054459-02S1 (PI: Lin).
Project II. Pharmacological intervention to prevent Alzheimer’s disease
(1) APOE Genotype-Dependent Pharmacogenetic Responses to Rapamycin for Preventing Alzheimer’s Disease. [Full article]
(2) Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease. [Full article]
(3) How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story. [Full article]
(4) Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease. [Full article]
(5) mTOR: Alzheimer’s disease prevention for APOE4 carriers. [Full article]
The project is funded by NIH/NIA R01AG054459, Donors Cure Foundation, University of Kentucky Alzheimer’s Disease Center, and Oklahoma Nathan Shock Center pilot grant (PI: Lin).
Project III. Caloric restriction to slow down brain aging
(1) Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity. [Full article]
(2) Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain. [Full article]
(3) Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice. [Full article]
(4) Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions. [Full article]
(5) Neuroimaging Biomarkers of Caloric Restriction on Brain Metabolic and Vascular Functions. [Full article]
(6) Caloric Restriction Alters Postprandial Responses of Essential Brain Metabolites in Young Adult Mice. [Full article]
The project was funded by NIH/NIA K01AG040164 and Young Investigator Award from the American Federation for Aging Research (AFAR) (PI: Lin).
Project IV. Novel MRI methods to calibrate translational cerebral blood flow measurements
(1) Novel Calibrated Short TR Recovery (CaSTRR) Method for Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast in Blood Flow Measurements in Mice. [Full article]
(2) Brain–Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method. [Full article]