Project I. Gut microbiome in stroke and traumatic brain injury

(1) Functional recovery outcomes following acute stroke is associated with abundance of gut microbiota related to inflammation, butyrate and secondary bile acid. [Full article]

(2) Gut microbial dysbiosis correlates with stroke severity markers in aged rats. [Full article]

(3) Inulin supplementation prior to mild traumatic brain injury mitigates gut dysbiosis, and brain vascular and white matter deficits in mice. [Full article]

(4) Inulin supplementation mitigates gut dysbiosis and brain impairment induced by mild traumatic brain injury during chronic phase. [Full article]

Project II. Gut microbiome in brain aging and Alzheimer’s disease

(1) Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome. [Full article

(2) Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice. [Full article]

(3) Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. [Full article]

(4) Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis. [Full article]


The project is funded by NIH/NIA RF1AG062480, and NIH/ODS R01AG054459-02S1 and RF1AG062480-01S1 (PI: Lin).

Project III. Artificial intelligence to identify targets for Alzheimer’s disease prevention and treatments

(1) Efficient training on Alzheimer’s disease diagnosis with learnable weighted pooling for 3D PET brain image classification. [Full article]

(2) β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline. [Full article

(3) Dynamic image for 3D MRI image Alzheimer’s disease. [Full article]

Project IV. Pharmacological intervention to prevent Alzheimer’s disease

(1) APOE Genotype-Dependent Pharmacogenetic Responses to Rapamycin for Preventing Alzheimer’s Disease. [Full article]

(2) Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease.  [Full article]

(3) How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story.  [Full article]

(4) Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease.  [Full article]

(5) mTOR: Alzheimer’s disease prevention for APOE4 carriers. [Full article]

The project is funded by NIH/NIA R01AG054459, New Vision Research (CCAD), University of Kentucky Alzheimer’s Disease Center, and Oklahoma Nathan Shock Center pilot grant (PI: Lin).

Project V. Caloric restriction to slow down brain aging

(1) Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity. [Full article]

(2) Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain.  [Full article]

(3) Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice.  [Full article]

(4) Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions.  [Full article]

(5) Neuroimaging Biomarkers of Caloric Restriction on Brain Metabolic and Vascular Functions. [Full article]

(6) Caloric Restriction Alters Postprandial Responses of Essential Brain Metabolites in Young Adult Mice. [Full article]

The project was funded by NIH/NIA K01AG040164 and Young Investigator Award from the American Federation for Aging Research (AFAR) (PI: Lin).

Project VI. Novel MRI methods to calibrate translational cerebral blood flow measurements

(1) Novel Calibrated Short TR Recovery (CaSTRR) Method for Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast in Blood Flow Measurements in Mice. [Full article]

(2) Brain–Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method. [Full article]