Research

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PubMed Full List

Google Scholar

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Project I. Modulate gut microbiome to protect brain functions

(1) Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome. [Full article

(2) Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice. [Full article]

(3) Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. [Full article]

The project is funded by NIH/NIA RF1AG062480 and NIH/ODS R01AG054459-02S1 (PI: Lin).

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Project II. Machine learning to identify targets for Alzheimer’s disease prevention and treatments

(1) β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline. [Full article

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Project III. Pharmacological intervention to prevent Alzheimer’s disease

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(1) APOE Genotype-Dependent Pharmacogenetic Responses to Rapamycin for Preventing Alzheimer’s Disease. [Full article]

(2) Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease.  [Full article]

(3) How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story.  [Full article]

(4) Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease.  [Full article]

(5) mTOR: Alzheimer’s disease prevention for APOE4 carriers. [Full article]

The project is funded by NIH/NIA R01AG054459, New Vision Research (CCAD), University of Kentucky Alzheimer’s Disease Center, and Oklahoma Nathan Shock Center pilot grant (PI: Lin).

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Project IV. Caloric restriction to slow down brain aging

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(1) Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity. [Full article]

(2) Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain.  [Full article]

(3) Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice.  [Full article]

(4) Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions.  [Full article]

(5) Neuroimaging Biomarkers of Caloric Restriction on Brain Metabolic and Vascular Functions. [Full article]

(6) Caloric Restriction Alters Postprandial Responses of Essential Brain Metabolites in Young Adult Mice. [Full article]

The project was funded by NIH/NIA K01AG040164 and Young Investigator Award from the American Federation for Aging Research (AFAR) (PI: Lin).

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 Project V. Novel MRI methods to calibrate translational cerebral blood flow measurements

(1) Novel Calibrated Short TR Recovery (CaSTRR) Method for Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast in Blood Flow Measurements in Mice. [Full article]

(2) Brain–Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method. [Full article]

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Follow Dr. Lin’s research on Twitter: (@linbrainlab)

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