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Project I. Caloric restriction to slow down brain aging

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(1) Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity. [Full Article]

(2) Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain. [Full Article]

(3) Early shifts of brain metabolism by caloric restriction preserve white matter integrity and long-term memory in aging mice. [Full Article]

(4) Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions. [Full Article]

(5) Neuroimaging biomarkers of caloric restriction on brain metabolic and vascular functions. [Full Article]

(6) Caloric Restriction Alters Postprandial Responses of Essential Brain Metabolites in Young Adult Mice. [Full Article]

**The project was funded by NIH/NIA K01AG040164 and American Federation for Aging Research (AFAR) (PI: Lin).


Project II. Pharmacological intervention to prevent Alzheimer’s disease

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(1) Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease. [Full Article

(2) How longevity research can lead to therapies for Alzheimer’s disease: The rapamycin story. [Full Article]

(3) Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease. [Full Article

(4) mTOR: Alzheimer’s disease prevention for APOE4 carriers. [Full Article]

(5) Neuroimaging biomarkers of mTOR inhibition on vascular and metabolic functions in aging brain and Alzheimer’s disease. [Full Article]

**The project is funded by NIH/NIA R01AG054459, Donors Cure Foundation, University of Kentucky Alzheimer’s Disease Center, and Oklahoma Nathan Shock Center of Excellence in the Biology of Aging (PI: Lin).


Project III. Modulate gut microbiome to protect brain functions

(1) Age drives distortion of brain metabolic, vascular and cognitive functions, and the gut microbiome. [Full Article]  

(2) Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice. [Full Article]

(3) Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. [Full Article]

**The project is funded by NIH/NIA RF1AG062480 and NIH/ODS R01AG054459-02S1 (PI: Lin).


Project IV. Novel MRI techniques to calibrate cerebral blood flow measurement

(1) Novel Calibrated Short TR Recovery (CaSTRR) Method for Brain-Blood Partition Coefficient Correction Enhances Gray-White Matter Contrast in Blood Flow Measurements in Mice. [Full Article]

(2) Brain-Blood Partition Coefficient and Cerebral Blood Flow in Canines Using Calibrated Short TR Recovery (CaSTRR) Correction Method. [Full Article]

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