Dr. Ai-Ling Lin

The mission of the Lin Brain Lab is to prevent Alzheimer’s disease by identifying effective pharmacological and nutritional interventions using neuroimaging, gut microbiome and multi-omics analyses, and machine/deep learning methods. The ultimate goal is to provide individualized solution with precision medicine via gut-brain axis.

The Lin Brain Lab is headed by Dr. Ai-Ling Lin, who is currently a tenured Associate Professor in the Sanders-Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, Department of Neuroscience and Department of Biomedical Engineering of the University of Kentucky.  Dr. Lin completed her PhD and Postdoctoral training as a medical physicist from the University of Texas Health Science Center in San Antonio, TX.  She has developed and applied multi-metric neuroimaging methods (MRI, MRS and PET) to quantify cerebral blood flow, and cerebral metabolic rates of glucose and oxygen in humans. She “reversely” translated the imaging techniques that she used in humans to animals, which allow her to identify effects of caloric restriction, ketogenic diet, prebiotic diet, and Rapamycin on cognitive aging and Alzheimer’s disease (AD) with various animal models. She has recently extended her research to include gut microbiome and metabolomic analyses, and machine leaning methods for identifying gut-brain interactions in the context of brain aging and AD. It is her goal to identify effective individualized interventions to preserve brain functions in aging and prevent AD via gut-brain axis.

Dr. Lin has been awarded $2.88 million from the National Institute on Aging to study Rapamycin’s potential to prevent Alzheimer’s disease, and another $3.61 million to study effects of prebiotic diet to reduce Alzheimer’s disease risk via gut-brain axis in an APOE4 mouse model.

Dr. Lin has numerous peer-reviewed articles, book chapters and poster awards to her credit, and directs or co-directs grants from the National Institute on Aging (NIA) and Office of Dietary Supplement (ODS) of the National Institutes of Health (NIH), the American Federation for Aging Research (AFAR), and the Donors Cure Foundation.

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