Finding paths for healthy brain aging
The research mission of Lin Brain Lab focuses on exploring nutritional and pharmacological interventions to decelerate brain aging, enhance recovery from stroke and traumatic brain injury, and minimize the risk of Alzheimer’s disease (AD), the predominant form of dementia. Leveraging advanced tools like neuroimaging, gut microbiome sequencing, transcriptomics, proteomics, and artificial intelligence, the lab intricately investigates the multifaceted nature of neurodegeneration. The future vision is to cultivate precision medicine and individualized nutritional strategies, specifically aimed at underlying genetic elements such as the APOE4 gene. We anticipate that these endeavors will lay the groundwork for a future in which brain aging, brain injury, and AD are not merely subjects of study but conditions effectively countered through tailored and precise interventions.
New article on gut microbiome and healthy aging
OUR RESEARCH ARTICLE KETOGENIC DIET ENHANCES NEUROVASCULAR FUNCTION WITH ALTERED GUT MICROBIOME IN YOUNG HEALTHY MICE IS SELECTED AS ONE OF THE TOP 100 READ PAPERS FOR SCIENTIFIC REPORTS IN 2018. #SREPTOP100
- APOE Genotype-Dependent Pharmacogenetic Responses to Rapamycin for Preventing Alzheimer’s Disease. [Full article]
- β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline (a machine learning study). [Full article]
- Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis. [Full article]
- Human gray and white matter metabolomics to differentiate APOE- and stage-dependent changes in Alzheimer’s disease. [Full article]