About us –
Finding paths for healthy brain aging
The research mission of Lin Brain Lab focuses on exploring nutritional and pharmacological interventions to decelerate brain aging, enhance recovery from stroke and traumatic brain injury, and minimize the risk of Alzheimer’s disease (AD), the predominant form of dementia. Leveraging advanced tools like neuroimaging, gut microbiome sequencing, transcriptomics, proteomics, and artificial intelligence, the lab intricately investigates the multifaceted nature of neurodegeneration. The future vision is to cultivate precision medicine and individualized nutritional strategies, specifically aimed at underlying genetic elements such as the APOE4 gene. We anticipate that these endeavors will lay the groundwork for a future in which brain aging, brain injury, and AD are not merely subjects of study but conditions effectively countered through tailored and precise interventions.
Recent Articles
Gut microbiome association with brain imaging markers, APOE genotype, calcium and vegetable intakes, and obesity in healthy aging adults. [Full article]
Prebiotic inulin enhances gut microbial metabolism and anti-inflammation in apolipoprotein E4 mice with sex-specific implications. [Full article].
APOE Genotype-Dependent Pharmacogenetic Responses to Rapamycin for Preventing Alzheimer’s Disease. [Full article]
Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis. [Full article]
β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline (a machine learning study). [Full article].
Human gray and white matter metabolomics to differentiate APOE- and stage-dependent changes in Alzheimer’s disease. [Full article]